Schedule
| Day | Game | Visitor Team | Score | Home Team | Score | Overtime | Shoot Out | Game Details |
|---|---|---|---|---|---|---|---|---|
| 2 | 10 | Montreal Canadiens | 3 | Buffalo Sabres | 4 | - | - | Scores |
| 5 | 37 | Vancouver Canucks | 0 | Buffalo Sabres | 2 | - | - | Scores |
| 6 | 55 | Boston Bruins | 6 | Buffalo Sabres | 2 | - | - | Scores |
| 8 | 66 | Buffalo Sabres | 1 | New Jersey Devils | 3 | - | - | Scores |
| 9 | 77 | Tampa Bay Lightning | 3 | Buffalo Sabres | 1 | - | - | Scores |
| 12 | 101 | Buffalo Sabres | 1 | Anaheim Ducks | 3 | - | - | Scores |
| 15 | 126 | Buffalo Sabres | 3 | Los Angeles Kings | 4 | True | True | Scores |
| 16 | 138 | Buffalo Sabres | 2 | San Jose Sharks | 3 | - | - | Scores |
| 18 | 152 | Buffalo Sabres | 6 | Seattle Kraken | 2 | - | - | Scores |
| 20 | 161 | Detroit Red Wings | 1 | Buffalo Sabres | 4 | - | - | Scores |
| 21 | 176 | Buffalo Sabres | 6 | Washington Capitals | 2 | - | - | Scores |
| 24 | 199 | Edmonton Oilers | 3 | Buffalo Sabres | 5 | - | - | Scores |
| 26 | 219 | Toronto Maple Leafs | 1 | Buffalo Sabres | 2 | - | - | Scores |
| 28 | 234 | Buffalo Sabres | 2 | Pittsburgh Penguins | 0 | - | - | Scores |
| 29 | 239 | Calgary Flames | 5 | Buffalo Sabres | 3 | - | - | Scores |
| 32 | 267 | Buffalo Sabres | 4 | New York Rangers | 2 | - | - | Scores |
| 33 | 274 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 35 | 290 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 36 | 303 | Montreal Canadiens | 0 | Buffalo Sabres | 0 | - | - | |
| 38 | 321 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 39 | 326 | Seattle Kraken | 0 | Buffalo Sabres | 0 | - | - | |
| 42 | 349 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 44 | 368 | Buffalo Sabres | 0 | Carolina Hurricanes | 0 | - | - | |
| 47 | 390 | Anaheim Ducks | 0 | Buffalo Sabres | 0 | - | - | |
| 48 | 396 | Arizona Coyotes | 0 | Buffalo Sabres | 0 | - | - | |
| 50 | 411 | New York Rangers | 0 | Buffalo Sabres | 0 | - | - | |
| 51 | 419 | Washington Capitals | 0 | Buffalo Sabres | 0 | - | - | |
| 54 | 448 | Buffalo Sabres | 0 | Winnipeg Jets | 0 | - | - | |
| 56 | 464 | Buffalo Sabres | 0 | Minnesota Wild | 0 | - | - | |
| 57 | 470 | Buffalo Sabres | 0 | Pittsburgh Penguins | 0 | - | - | |
| 60 | 492 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 61 | 509 | Colorado Avalanche | 0 | Buffalo Sabres | 0 | - | - | |
| 63 | 519 | Buffalo Sabres | 0 | Columbus Blue Jackets | 0 | - | - | |
| 64 | 528 | New York Islanders | 0 | Buffalo Sabres | 0 | - | - | |
| 66 | 544 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 67 | 558 | Buffalo Sabres | 0 | New York Islanders | 0 | - | - | |
| 69 | 569 | Buffalo Sabres | 0 | Boston Bruins | 0 | - | - | |
| 74 | 610 | San Jose Sharks | 0 | Buffalo Sabres | 0 | - | - | |
| 75 | 618 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 78 | 648 | Tampa Bay Lightning | 0 | Buffalo Sabres | 0 | - | - | |
| 79 | 658 | Buffalo Sabres | 0 | Nashville Predators | 0 | - | - | |
| 81 | 672 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 83 | 684 | Detroit Red Wings | 0 | Buffalo Sabres | 0 | - | - | |
| 84 | 694 | Buffalo Sabres | 0 | Ottawa Senators | 0 | - | - | |
| 86 | 707 | Dallas Stars | 0 | Buffalo Sabres | 0 | - | - | |
| 88 | 723 | Philadelphia Flyers | 0 | Buffalo Sabres | 0 | - | - | |
| 91 | 746 | Buffalo Sabres | 0 | Ottawa Senators | 0 | - | - | |
| 95 | 783 | Buffalo Sabres | 0 | Arizona Coyotes | 0 | - | - | |
| 96 | 792 | Buffalo Sabres | 0 | Colorado Avalanche | 0 | - | - | |
| 98 | 808 | Buffalo Sabres | 0 | Vegas Golden Knights | 0 | - | - | |
| 100 | 824 | Buffalo Sabres | 0 | St. Louis Blues | 0 | - | - | |
| 103 | 841 | Buffalo Sabres | 0 | Dallas Stars | 0 | - | - | |
| 105 | 860 | Buffalo Sabres | 0 | Toronto Maple Leafs | 0 | - | - | |
| 107 | 875 | Minnesota Wild | 0 | Buffalo Sabres | 0 | - | - | |
| 109 | 900 | Florida Panthers | 0 | Buffalo Sabres | 0 | - | - | |
| 111 | 907 | Los Angeles Kings | 0 | Buffalo Sabres | 0 | - | - | |
| 112 | 916 | Vegas Golden Knights | 0 | Buffalo Sabres | 0 | - | - | |
| 115 | 942 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 118 | 973 | Buffalo Sabres | 0 | Edmonton Oilers | 0 | - | - | |
| 119 | 980 | Buffalo Sabres | 0 | Calgary Flames | 0 | - | - | |
| 121 | 999 | Buffalo Sabres | 0 | Vancouver Canucks | 0 | - | - | |
| 124 | 1016 | Pittsburgh Penguins | 0 | Buffalo Sabres | 0 | - | - | |
| 126 | 1029 | Washington Capitals | 0 | Buffalo Sabres | 0 | - | - | |
| 128 | 1048 | Buffalo Sabres | 0 | New York Rangers | 0 | - | - | |
| 129 | 1057 | Buffalo Sabres | 0 | Chicago Blackhawks | 0 | - | - | |
| 131 | 1069 | Winnipeg Jets | 0 | Buffalo Sabres | 0 | - | - | |
| 133 | 1084 | Nashville Predators | 0 | Buffalo Sabres | 0 | - | - | |
| 135 | 1101 | Florida Panthers | 0 | Buffalo Sabres | 0 | - | - | |
| 137 | 1115 | Carolina Hurricanes | 0 | Buffalo Sabres | 0 | - | - | |
| 139 | 1134 | Buffalo Sabres | 0 | Carolina Hurricanes | 0 | - | - | |
| 140 | 1141 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 142 | 1158 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - | |
| 143 | 1164 | Buffalo Sabres | 0 | Toronto Maple Leafs | 0 | - | - | |
| 145 | 1182 | St. Louis Blues | 0 | Buffalo Sabres | 0 | - | - | |
| 147 | 1200 | Philadelphia Flyers | 0 | Buffalo Sabres | 0 | - | - | |
| 148 | 1211 | Buffalo Sabres | 0 | Philadelphia Flyers | 0 | - | - | |
| 151 | 1229 | Ottawa Senators | 0 | Buffalo Sabres | 0 | - | - | |
| 152 | 1236 | Buffalo Sabres | 0 | New Jersey Devils | 0 | - | - | |
| 154 | 1249 | New York Islanders | 0 | Buffalo Sabres | 0 | - | - | |
| 156 | 1273 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 158 | 1290 | Buffalo Sabres | 0 | Boston Bruins | 0 | - | - | |
| 159 | 1298 | Chicago Blackhawks | 0 | Buffalo Sabres | 0 | - | - |